The USP7 protein interaction network and its roles in tumorigenesis

Ahood Al-Eidan; Yihua Wang; Paul Skipp; Rob M. Ewing

doi:10.1016/j.gendis.2020.10.004

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The USP7 protein interaction network and its roles in tumorigenesis

Review article | 更新时间：2022-06-24

- The USP7 protein interaction network and its roles in tumorigenesis
- The USP7 protein interaction network and its roles in tumorigenesis
- Genes & Diseases 2022年9卷第1期
- 作者机构：
  
  1. School of Biological Sciences, B85 Life Sciences, University of Southampton,Southampton,UK,SO17 1BJ
  2. Department of Biology, College of Sciences, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam, Saudi Arabia
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2020.10.004
  中图分类号：
- 纸质出版日期：2022，
  
  网络出版日期：2022-1-1，
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Ahood Al-Eidan, Yihua Wang, Paul Skipp, 等. The USP7 protein interaction network and its roles in tumorigenesis[J]. Genes & Diseases, 2022,9(1).

Ahood Al-Eidan, Yihua Wang, Paul Skipp, et al. The USP7 protein interaction network and its roles in tumorigenesis[J]. Genes & Diseases, 2022,9(1).
Ahood Al-Eidan, Yihua Wang, Paul Skipp, 等. The USP7 protein interaction network and its roles in tumorigenesis[J]. Genes & Diseases, 2022,9(1). DOI： 10.1016/j.gendis.2020.10.004.

Ahood Al-Eidan, Yihua Wang, Paul Skipp, et al. The USP7 protein interaction network and its roles in tumorigenesis[J]. Genes & Diseases, 2022,9(1). DOI： 10.1016/j.gendis.2020.10.004.

摘要

Abstract

Ubiquitin-specific protease (USP7)

also known as Herpesvirus-associated ubiquitin-specific protease (HAUSP)

is a deubiquitinase. There has been significant recent attention on USP7 following the discovery that USP7 is a key regulator of the p53-MDM2 pathway. The USP7 protein is 130 kDa in size and has multiple domains which bind to a diverse set of proteins. These interactions mediate key developmental and homeostatic processes including the cell cycle

immune response

and modulation of transcription factor and epigenetic regulator activity and localization. USP7 also promotes carcinogenesis through aberrant activation of the Wnt signalling pathway and stabilization of HIF-1α. These findings have shown that USP7 may induce tumour progression and be a therapeutic target. Together with interest in developing USP7 as a target

several studies have defined new protein interactions and the regulatory networks within which USP7 functions. In this review

we focus on the protein interactions of USP7 that are most important for its cancer-associated roles.

关键词

Keywords

CancerDeubiquitinaseProtein networkProtein–protein interactionProteomicsUSP7

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