The mitophagy receptor FUN14 domain-containing 1 (FUNDC1): A promising biomarker and potential therapeutic target of human diseases

Weilin Zhang

doi:10.1016/j.gendis.2020.08.011

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The mitophagy receptor FUN14 domain-containing 1 (FUNDC1): A promising biomarker and potential therapeutic target of human diseases

Review article | 更新时间：2022-06-24

- The mitophagy receptor FUN14 domain-containing 1 (FUNDC1): A promising biomarker and potential therapeutic target of human diseases
- The mitophagy receptor FUN14 domain-containing 1 (FUNDC1): A promising biomarker and potential therapeutic target of human diseases
- Genes & Diseases 2021年8卷第5期
- 作者机构：
  
  State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences,Beijing,PR China,100864
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2020.08.011
  中图分类号：
- 纸质出版日期：2021，
  
  网络出版日期：2021-9-1，
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Weilin Zhang. The mitophagy receptor FUN14 domain-containing 1 (FUNDC1): A promising biomarker and potential therapeutic target of human diseases[J]. Genes & Diseases, 2021,8(5).

Weilin Zhang. The mitophagy receptor FUN14 domain-containing 1 (FUNDC1): A promising biomarker and potential therapeutic target of human diseases[J]. Genes & Diseases, 2021,8(5).
Weilin Zhang. The mitophagy receptor FUN14 domain-containing 1 (FUNDC1): A promising biomarker and potential therapeutic target of human diseases[J]. Genes & Diseases, 2021,8(5). DOI： 10.1016/j.gendis.2020.08.011.

Weilin Zhang. The mitophagy receptor FUN14 domain-containing 1 (FUNDC1): A promising biomarker and potential therapeutic target of human diseases[J]. Genes & Diseases, 2021,8(5). DOI： 10.1016/j.gendis.2020.08.011.

摘要

Abstract

Mitochondrial autophagy (mitophagy) is the selective clearance of damaged or incomplete mitochondria by autophagy

which is critical for the functional integrity of the entire mitochondrial network and cell survival. Because dysfunction of mitophagy is closely related to many diseases

it is important to study the specific molecular mechanism and pathophysiological significance of mitophagy. FUN14 domain-containing 1 (FUNDC1) is a newly identified mitochondrial outer membrane protein that induces receptor-mediated mitophagy by its interaction with LC3 during hypoxia. The expression

phosphorylation

regulation and significance of FUNDC1 are reviewed in the context of a large number of pathophysiological conditions. Emerging evidence has demonstrated that levels and phosphorylation states of FUNDC1 are closely related to occurrence

progression and prognosis of various diseases including heart diseases and cancers

indicating that FUNDC1 may serve as a promising biomarker and potential therapeutic target.

关键词

Keywords

AutophagyBiomarkerFUNDC1Heart diseasesHypoxiaMitochondriaMitochondrial ROSPlatelets

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