Melatonin antagonizes ovarian aging via YTHDF2-MAPK-NF-κB pathway

Ruigong Zhu; Xian Ji; Xuan Wu; Jiajing Chen; Xuesong Li; Hong Jiang; Haiping Fu; Hui Wang; Zhe Lin; Xin Tang; Shixiu Sun; Qingguo Li; Bingjian Wang; Hongshan Chen

doi:10.1016/j.gendis.2020.08.005

您当前的位置：

首页 >

文章列表页 >

Melatonin antagonizes ovarian aging via YTHDF2-MAPK-NF-κB pathway

Full-length article | 更新时间：2022-06-24

- Melatonin antagonizes ovarian aging via YTHDF2-MAPK-NF-κB pathway
- Melatonin antagonizes ovarian aging via YTHDF2-MAPK-NF-κB pathway
- Genes & Diseases 2022年9卷第2期
- 作者机构：
  
  1. Key Laboratory of Cardiovascular & Cerebrovascular Medicine, School of Pharmacy, Nanjing Medical University,Jiangsu,Nanjing,PR China,211166
  2. Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Nanjing Medical University,Jiangsu,Nanjing,PR China,210003
  3. Department of Cardiology, Huai'an First People's Hospital Affiliated with Nanjing Medical University,Jiangsu,Huai'an,PR China,223399
  4. Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University,Jiangsu,Nanjing,PR China,211166
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2020.08.005
  中图分类号：
- 纸质出版日期：2022，
  
  网络出版日期：2022-3-1，
扫描看全文
Ruigong Zhu, Xian Ji, Xuan Wu, 等. Melatonin antagonizes ovarian aging via YTHDF2-MAPK-NF-κB pathway[J]. Genes & Diseases, 2022,9(2).

Ruigong Zhu, Xian Ji, Xuan Wu, et al. Melatonin antagonizes ovarian aging via YTHDF2-MAPK-NF-κB pathway[J]. Genes & Diseases, 2022,9(2).
Ruigong Zhu, Xian Ji, Xuan Wu, 等. Melatonin antagonizes ovarian aging via YTHDF2-MAPK-NF-κB pathway[J]. Genes & Diseases, 2022,9(2). DOI： 10.1016/j.gendis.2020.08.005.

Ruigong Zhu, Xian Ji, Xuan Wu, et al. Melatonin antagonizes ovarian aging via YTHDF2-MAPK-NF-κB pathway[J]. Genes & Diseases, 2022,9(2). DOI： 10.1016/j.gendis.2020.08.005.

摘要

Abstract

Cellular senescence is closely associated with age-related diseases. Ovarian aging

a special type of organ senescence

is the pathophysiological foundation of the diseases of the reproductive system. It is characterized by the loss of integrity of the surface epithelium and a gradual decrease in the number of human ovarian surface epithelial cells (HOSEpiCs). To contribute to the research on delaying ovarian aging

we aimed to investigate the novel epigenetic mechanism of melatonin in protecting HOSEpiCs. We discovered that melatonin has antagonistic effects against the oncogene-induced senescence (OIS) of HOSEpiCs. Mechanistically

the oncogene Ras decreased the expression of YTHDF2

which is the reader of RNA-m

by stimulating the generation of reactive oxygen species (ROS). Moreover

we found that the suppression of

YTHDF2

increased the expression of

MAP2K4

and

MAP4K4

by enhancing the stability of the transcription of their mRNAs

thereby upregulating the expression of the senescence-associated secretory phenotype (SASP) through the activation of the MAP2K4 and MAP4K4-dependent nuclear factor-κB (NF-κB) signaling pathways. We further determined that melatonin has antagonistic effects against the OIS of HOSEpiCs by inhibiting the ROS-YTHDF2-MAPK-NF-κB pathway. These findings provide key insights into the potential avenues for preventing and treating ovarian aging.

关键词

Keywords

Gene expressionInflammationMelatoninSenescenceYTHDF2

references

查看原文

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

The journey towards physiology and pathology: Tracing the path of neuregulin 4

RNA m⁶A reader YTHDF2 facilitates precursor miR-126 maturation to promote acute myeloid leukemia progression

DEAD-box RNA helicases with special reference to p68: Unwinding their biology, versatility, and therapeutic opportunity in cancer

The emerging role of Arid5a in cancer: A new target for tumors

Molecular and cellular pathophysiology of circulating cardiomyocyte-specific cell free DNA (cfDNA): Biomarkers of heart failure and potential therapeutic targets