PTPN18 promotes colorectal cancer progression by regulating the c-MYC-CDK4 axis

Chao Li; Shang-Ze Li; Xi-Cheng Huang; Jie Chen; Wenbin Liu; Xiao-Dong Zhang; Xue-Min Song; Run-Lei Du

doi:10.1016/j.gendis.2020.08.001

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PTPN18 promotes colorectal cancer progression by regulating the c-MYC-CDK4 axis

Full-length article | 更新时间：2022-06-24

- PTPN18 promotes colorectal cancer progression by regulating the c-MYC-CDK4 axis
- PTPN18 promotes colorectal cancer progression by regulating the c-MYC-CDK4 axis
- Genes & Diseases 2021年8卷第6期
- 作者机构：
  
  1. Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University,Hubei Province,Wuhan,PR China,430072
  2. Research Centre of Anesthesiology and Critical Care Medicine, Zhongnan Hospital of Wuhan University,Hubei Province,Wuhan,PR China,430071
  3. College of Health Sciences and Nursing, Wuhan Polytechnic University,Hubei Province,Wuhan,PR China,430023
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2020.08.001
  中图分类号：
- 纸质出版日期：2021，
  
  网络出版日期：2021-11-1，
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Chao Li, Shang-Ze Li, Xi-Cheng Huang, 等. PTPN18 promotes colorectal cancer progression by regulating the c-MYC-CDK4 axis[J]. Genes & Diseases, 2021,8(6).

Chao Li, Shang-Ze Li, Xi-Cheng Huang, et al. PTPN18 promotes colorectal cancer progression by regulating the c-MYC-CDK4 axis[J]. Genes & Diseases, 2021,8(6).
Chao Li, Shang-Ze Li, Xi-Cheng Huang, 等. PTPN18 promotes colorectal cancer progression by regulating the c-MYC-CDK4 axis[J]. Genes & Diseases, 2021,8(6). DOI： 10.1016/j.gendis.2020.08.001.

Chao Li, Shang-Ze Li, Xi-Cheng Huang, et al. PTPN18 promotes colorectal cancer progression by regulating the c-MYC-CDK4 axis[J]. Genes & Diseases, 2021,8(6). DOI： 10.1016/j.gendis.2020.08.001.

摘要

Abstract

Protein tyrosine phosphatase non-receptor type 18 (PTPN18) is often highly expressed in colorectal cancer (CRC)

but its role in this disease remains unclear. We demonstrated that PTPN18 overexpression promotes growth and tumorigenesis in CRC cells and that PTPN18 deficiency yields the opposite results

in vitro

. Moreover

a xenograft assay showed that PTPN18 deficiency significantly inhibited tumorigenesis

in vivo

. PTPN18 activated the MYC signaling pathway and enhanced CDK4 expression

which is tightly associated with the cell cycle and proliferation in cancer cells. Finally

we found that MYC interacted with PTPN18 and increased the protein level of MYC. In conclusion

our results suggest that PTPN18 promotes CRC development by stabilizing the MYC protein level

which in turn activates the MYC-CDK4 axis. Thus

PTPN18 could be a novel therapeutic target in the future.

关键词

Keywords

CDK4Colorectal cancerMYCProliferationPTPN18

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