Regeneration and activation of liver progenitor cells in liver cirrhosis

Yanze Yin; Defu Kong; Kang He; Qiang Xia

doi:10.1016/j.gendis.2020.07.016

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Regeneration and activation of liver progenitor cells in liver cirrhosis

Review article | 更新时间：2022-06-24

- Regeneration and activation of liver progenitor cells in liver cirrhosis
- Regeneration and activation of liver progenitor cells in liver cirrhosis
- Genes & Diseases 2021年8卷第5期
- 作者机构：
  
  1. Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University,Shanghai,PR China,200240
  2. Department of Hepatology & Gastroenterology, University Medical Center Groningen,Groningen,the Netherlands,9713
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2020.07.016
  中图分类号：
- 纸质出版日期：2021，
  
  网络出版日期：2021-9-1，
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Yanze Yin, Defu Kong, Kang He, 等. Regeneration and activation of liver progenitor cells in liver cirrhosis[J]. Genes & Diseases, 2021,8(5).

Yanze Yin, Defu Kong, Kang He, et al. Regeneration and activation of liver progenitor cells in liver cirrhosis[J]. Genes & Diseases, 2021,8(5).
Yanze Yin, Defu Kong, Kang He, 等. Regeneration and activation of liver progenitor cells in liver cirrhosis[J]. Genes & Diseases, 2021,8(5). DOI： 10.1016/j.gendis.2020.07.016.

Yanze Yin, Defu Kong, Kang He, et al. Regeneration and activation of liver progenitor cells in liver cirrhosis[J]. Genes & Diseases, 2021,8(5). DOI： 10.1016/j.gendis.2020.07.016.

摘要

Abstract

Cirrhosis is characterized as the progress of regenerative nodules surrounded by fibrous bands in response to chronic hepatic injury and causes portal hypertension and end-stage hepatic disease. Following liver injury

liver progenitor cells (LPCs) can be activated and differentiate into hepatocytes in order to awaken liver regeneration and reach homeostasis. Recent research has uncovered some new sources of LPCs. Here

we update the mechanisms of LPCs-mediated liver regeneration in cirrhosis by introducing the origin of LPCs and LPCs’ niche with a discussion of the influence of LPC-related cells. This article analyzes the mechanism of regeneration and activation of LPCs in cirrhosis in recent years aiming to provide help for clinical application.

关键词

Keywords

ActivationCytokinesExtracellular matrixHepatic stellate cellsLiver cirrhosisLiver progenitor cellsLiver regenerationNiche

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