Reversible N6-methyladenosine of RNA: The regulatory mechanisms on gene expression and implications in physiology and pathology

Xinyu Fang; Mengyang Li; Tao Yu; Gaoli Liu; Jianxun Wang

doi:10.1016/j.gendis.2020.06.011

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Reversible N6-methyladenosine of RNA: The regulatory mechanisms on gene expression and implications in physiology and pathology

Review article | 更新时间：2022-06-24

- Reversible N6-methyladenosine of RNA: The regulatory mechanisms on gene expression and implications in physiology and pathology
- Reversible N6-methyladenosine of RNA: The regulatory mechanisms on gene expression and implications in physiology and pathology
- Genes & Diseases 2020年7卷第4期
- 作者机构：
  
  1. School of Basic Medicine, Qingdao University,Qingdao,China,266071
  2. Institute for Translational Medicine, Qingdao University,Qingdao,China,266021
  3. Department of Cardiovascular Surgery, Affiliated Hospital, Qingdao University,Qingdao,China,266510
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2020.06.011
  中图分类号：
- 纸质出版日期：2020，
  
  网络出版日期：2020-12-1，
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Xinyu Fang, Mengyang Li, Tao Yu, 等. Reversible N6-methyladenosine of RNA: The regulatory mechanisms on gene expression and implications in physiology and pathology[J]. Genes & Diseases, 2020,7(4).

Xinyu Fang, Mengyang Li, Tao Yu, et al. Reversible N6-methyladenosine of RNA: The regulatory mechanisms on gene expression and implications in physiology and pathology[J]. Genes & Diseases, 2020,7(4).
Xinyu Fang, Mengyang Li, Tao Yu, 等. Reversible N6-methyladenosine of RNA: The regulatory mechanisms on gene expression and implications in physiology and pathology[J]. Genes & Diseases, 2020,7(4). DOI： 10.1016/j.gendis.2020.06.011.

Xinyu Fang, Mengyang Li, Tao Yu, et al. Reversible N6-methyladenosine of RNA: The regulatory mechanisms on gene expression and implications in physiology and pathology[J]. Genes & Diseases, 2020,7(4). DOI： 10.1016/j.gendis.2020.06.011.

摘要

Abstract

N6-methyladenosine (m6A) is the most abundant inner RNA modification in eukaryotes. Due to the development of RNA sequencing technology

the distribution pattern of m6A in the transcriptome has been uncovered. Dynamically

the reversible N6-methylation is mediated by two types of proteins

which are classified as “writers” and “erasers”. Under the association of specific co-factors

writers show spatiotemporal N6-methyltransferase activity. Mechanically

m6A can be recognized by “reader” proteins or can directly modify RNA conformation

and it widely affects gene expression by mediating RNA stability

translation

splicing and export. m6A is involved in a series of physiology processes. Dysregulation of m6A is gradually defined as the pathogenesis of some diseases

e.g.

cancer and cardiovascular disease. Therefore

a good understanding of m6A is essential for molecular biology and pathology research. In this article we systemically present an overview of the functions and mechanisms of identified m6A regulators. The discovered biological and pathological processes affected by m6A are also summarized. We hope that readers with related research interests benefit from our review.

关键词

Keywords

DiseasesEpigeneticsGene expressionm6Am6A regulatorRNA

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