Coronavirus disease 2019 (COVID-19): cytokine storms, hyper-inflammatory phenotypes, and acute respiratory distress syndrome

Shi-hui Lin; Yi-si Zhao; Dai-xing Zhou; Fa-chun Zhou; Fang Xu

doi:10.1016/j.gendis.2020.06.009

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Coronavirus disease 2019 (COVID-19): cytokine storms, hyper-inflammatory phenotypes, and acute respiratory distress syndrome

Review article | 更新时间：2022-06-24

- Coronavirus disease 2019 (COVID-19): cytokine storms, hyper-inflammatory phenotypes, and acute respiratory distress syndrome
- Coronavirus disease 2019 (COVID-19): cytokine storms, hyper-inflammatory phenotypes, and acute respiratory distress syndrome
- Genes & Diseases 2020年7卷第4期
- 作者机构：
  
  1. Department of Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University,Chongqing,China
  2. Department of Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan,China
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2020.06.009
  中图分类号：
- 纸质出版日期：2020，
  
  网络出版日期：2020-12-1，
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Shi-hui Lin, Yi-si Zhao, Dai-xing Zhou, 等. Coronavirus disease 2019 (COVID-19): cytokine storms, hyper-inflammatory phenotypes, and acute respiratory distress syndrome[J]. Genes & Diseases, 2020,7(4).

Shi-hui Lin, Yi-si Zhao, Dai-xing Zhou, et al. Coronavirus disease 2019 (COVID-19): cytokine storms, hyper-inflammatory phenotypes, and acute respiratory distress syndrome[J]. Genes & Diseases, 2020,7(4).
Shi-hui Lin, Yi-si Zhao, Dai-xing Zhou, 等. Coronavirus disease 2019 (COVID-19): cytokine storms, hyper-inflammatory phenotypes, and acute respiratory distress syndrome[J]. Genes & Diseases, 2020,7(4). DOI： 10.1016/j.gendis.2020.06.009.

Shi-hui Lin, Yi-si Zhao, Dai-xing Zhou, et al. Coronavirus disease 2019 (COVID-19): cytokine storms, hyper-inflammatory phenotypes, and acute respiratory distress syndrome[J]. Genes & Diseases, 2020,7(4). DOI： 10.1016/j.gendis.2020.06.009.

摘要

Abstract

Coronavirus Disease 2019 (COVID-19) was first identified in China at the end of 2019. Acute respiratory distress syndrome (ARDS) represents the most common and serious complication of COVID-19. Cytokine storms are a pathophysiological feature of COVID-19 and play an important role in distinguishing hyper-inflammatory subphenotypes of ARDS. Accordingly

in this review

we focus on hyper-inflammatory host responses in ARDS that play a critical role in the differentiated development of COVID-19. Furthermore

we discuss inflammation-related indicators that have the potential to identify hyper-inflammatory subphenotypes of COVID-19

especially for those with a high risk of ARDS. Finally

we explore the possibility of improving the quality of monitoring and treatment of COVID-19 patients and in reducing the incidence of critical illness and mortality via better distinguishing hyper- and hypo-inflammatory subphenotypes of COVID-19.

关键词

Keywords

Acute respiratory distress syndromeCOVID-19Cytokine stormHyper-inflammatory host responseSARS-Cov-2

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