Known drugs and small molecules in the battle for COVID-19 treatment

Alexios A. Panoutsopoulos

doi:10.1016/j.gendis.2020.06.007

您当前的位置：

首页 >

文章列表页 >

Known drugs and small molecules in the battle for COVID-19 treatment

Review article | 更新时间：2022-06-24

- Known drugs and small molecules in the battle for COVID-19 treatment
- Known drugs and small molecules in the battle for COVID-19 treatment
- Genes & Diseases 2020年7卷第4期
- 作者机构：
  
  1. Department of Pathology and Laboratory Medicine, University of California, Davis,CA,USA
  2. Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children,Northern California, 2425 Stockton Boulevard, Sacramento,CA,USA,95817
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2020.06.007
  中图分类号：
- 纸质出版日期：2020，
  
  网络出版日期：2020-12-1，
扫描看全文
Alexios A. Panoutsopoulos. Known drugs and small molecules in the battle for COVID-19 treatment[J]. Genes & Diseases, 2020,7(4).

Alexios A. Panoutsopoulos. Known drugs and small molecules in the battle for COVID-19 treatment[J]. Genes & Diseases, 2020,7(4).
Alexios A. Panoutsopoulos. Known drugs and small molecules in the battle for COVID-19 treatment[J]. Genes & Diseases, 2020,7(4). DOI： 10.1016/j.gendis.2020.06.007.

Alexios A. Panoutsopoulos. Known drugs and small molecules in the battle for COVID-19 treatment[J]. Genes & Diseases, 2020,7(4). DOI： 10.1016/j.gendis.2020.06.007.

摘要

Abstract

COVID-19 has been declared a pandemic by the World Health Organization on March 11th and since then more than 3 million cases and a quarter million deaths have occurred due to it. The urge to find a resultful treatment or cure is now pressing more than any other time since the outbreak of the pandemic. Researchers all over the world from different fields of expertise are trying to find the most suitable drugs

that are already known to treat other diseases

and could tackle the process of SARS-CoV2 through which it invades and replicates in human cells. Here

we discuss five of the most promising drugs that can potentially play a major role in the treatment of COVID-19. While nicotine and ivermectin may be blocking transport abilities of the virus or its components

famotidine

remdesivir and chloroquine in combination with zinc ions can deactivate important enzymes needed for the replication of the virus. While clinical trials for some of these drugs have already started

it is common knowledge that lack of organization between countries

institutes and hospitals might slow down the whole process for an official treatment based in wide

randomized

placebo controlled trials.

关键词

Keywords

ChloroquineCoronavirusCOVID-19FamotidineIvermectinNicotineRemdesivirSARS-Cov2

references

查看原文

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

Pandemic COVID-19: Current status and challenges of antiviral therapies

Unclear but present danger: An asymptomatic SARS-CoV-2 carrier

COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery

Advances of CRISPR-Cas13 system in COVID-19 diagnosis and treatment

Single-cell transcriptome landscape and antigen receptor dynamic during SARS-CoV-2 vaccination