THBS1 regulates trophoblast fusion through a CD36-dependent inhibition of cAMP, and its upregulation participates in preeclampsia

Fu-Mei Duan; Li-Juan Fu; Yong-Heng Wang; Enoch Appiah Adu-Gyamfi; Ling- Ling Ruan; Zeng-Wei Xu; Shi-Quan Xiao; Xue-Mei Chen; Ying-Xiong Wang; Tai-Hang Liu; Yu-Bin Ding

doi:10.1016/j.gendis.2020.05.007

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THBS1 regulates trophoblast fusion through a CD36-dependent inhibition of cAMP, and its upregulation participates in preeclampsia

Full-length article | 更新时间：2022-06-24

- THBS1 regulates trophoblast fusion through a CD36-dependent inhibition of cAMP, and its upregulation participates in preeclampsia
- THBS1 regulates trophoblast fusion through a CD36-dependent inhibition of cAMP, and its upregulation participates in preeclampsia
- Genes & Diseases 2021年8卷第3期
- 作者机构：
  
  1. School of Public Health and Management, Chongqing Medical University,Chongqing,PR China,400016
  2. Department of Herbal Medicine, School of Traditional Chinese Medicine, Chongqing Medical University,Chongqing,PR China,400016
  3. The Joint International Research Laboratory of Reproduction and Development, Ministry of Education,Chongqing,PR China,400016
  4. Department of Reproductive Medicine, The Third Affiliated Hospital, Chongqing Medical University,Chongqing,PR China,401120
  5. Department of Bioinformatics, The School of Basic Medicine, Chongqing Medical University,Chongqing,PR China,400016
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2020.05.007
  中图分类号：
- 纸质出版日期：2021，
  
  网络出版日期：2021-5-1，
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Fu-Mei Duan, Li-Juan Fu, Yong-Heng Wang, 等. THBS1 regulates trophoblast fusion through a CD36-dependent inhibition of cAMP, and its upregulation participates in preeclampsia[J]. Genes & Diseases, 2021,8(3).

Fu-Mei Duan, Li-Juan Fu, Yong-Heng Wang, et al. THBS1 regulates trophoblast fusion through a CD36-dependent inhibition of cAMP, and its upregulation participates in preeclampsia[J]. Genes & Diseases, 2021,8(3).
Fu-Mei Duan, Li-Juan Fu, Yong-Heng Wang, 等. THBS1 regulates trophoblast fusion through a CD36-dependent inhibition of cAMP, and its upregulation participates in preeclampsia[J]. Genes & Diseases, 2021,8(3). DOI： 10.1016/j.gendis.2020.05.007.

Fu-Mei Duan, Li-Juan Fu, Yong-Heng Wang, et al. THBS1 regulates trophoblast fusion through a CD36-dependent inhibition of cAMP, and its upregulation participates in preeclampsia[J]. Genes & Diseases, 2021,8(3). DOI： 10.1016/j.gendis.2020.05.007.

摘要

Abstract

Preeclampsia is a pregnancy complication which threatens the survival of mothers and fetuses. It originates from abnormal placentation

especially insufficient fusion of the cytotrophoblast cells to form the syncytiotrophoblast. In this study

we found that THBS1

a matricellular protein that mediates cell-to-cell and cell-to-matrix interactions

is downregulated during the fusion of primary cytotrophoblast and BeWo cells

but upregulated in the placenta of pregnancies complicated by preeclampsia. Also

THBS1 was observed to interact with CD36

a membrane signal receptor and activator of the cAMP signaling pathway

to regulate the fusion of cytotrophoblast cells. Overexpression of THBS1 inhibited the cAMP signaling pathway and reduced the BeWo cells fusion ratio

while the effects of THBS1 were abolished by a CD36-blocking antibody. Our results suggest that THBS1 signals through a CD36-mediated cAMP pathway to regulate syncytialization of the cytotrophoblast cells

and that its upregulation impairs placental formation to cause preeclampsia. Thus

THBS1 can serve as a therapeutic target regarding the mitigation of abnormal syncytialization and preeclampsia.

关键词

Keywords

cAMPCell fusionPreeclampsiaTHBS1Trophoblast

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