Functional roles of lncRNAs in the pathogenesis and progression of cancer

Alireza Ahadi

doi:10.1016/j.gendis.2020.04.009

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Functional roles of lncRNAs in the pathogenesis and progression of cancer

Review article | 更新时间：2022-06-24

- Functional roles of lncRNAs in the pathogenesis and progression of cancer
- Functional roles of lncRNAs in the pathogenesis and progression of cancer
- Genes & Diseases 2021年8卷第4期
- 作者机构：
  
  Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, 198396,Iran,3113
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2020.04.009
  中图分类号：
- 纸质出版日期：2021，
  
  网络出版日期：2021-7-1，
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Alireza Ahadi. Functional roles of lncRNAs in the pathogenesis and progression of cancer[J]. Genes & Diseases, 2021,8(4).

Alireza Ahadi. Functional roles of lncRNAs in the pathogenesis and progression of cancer[J]. Genes & Diseases, 2021,8(4).
Alireza Ahadi. Functional roles of lncRNAs in the pathogenesis and progression of cancer[J]. Genes & Diseases, 2021,8(4). DOI： 10.1016/j.gendis.2020.04.009.

Alireza Ahadi. Functional roles of lncRNAs in the pathogenesis and progression of cancer[J]. Genes & Diseases, 2021,8(4). DOI： 10.1016/j.gendis.2020.04.009.

摘要

Abstract

Long noncoding RNAs (lncRNAs) act as regulators of gene expression and pivotal transcriptional regulators in cancer cells via diverse mechanisms. lncRNAs involves a variety of pathological and biological activities

such as apoptosis

cell proliferation

metastasis

and invasion. By using microarray and RNA sequencing

it was identified that dysregulation of lncRNAs affects the tumorigenesis process. Taken together

these lncRNAs are putative biomarker and therapeutic target in human malignancies. In this review

I discuss the latest finding regarding the dysregulation of some important lncRNAs and their diverse mechanisms of these lncRNAs in the pathogenesis and progression of certain cancers; also

I summarize the possible roles of lncRNAs in clinical application for diagnosis and prognosis of cancer.

关键词

Keywords

BiomarkerCancerDysregulationLncRNANcRNA

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