Adverse effects of chemoradiotherapy on invasion and metastasis of tumor cells

Wei Xiong; Yong Liao; Ji-Yong Qin; Wen-Hui Li; Zhao-You Tang

doi:10.1016/j.gendis.2020.04.004

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Adverse effects of chemoradiotherapy on invasion and metastasis of tumor cells

Review article | 更新时间：2022-06-24

- Adverse effects of chemoradiotherapy on invasion and metastasis of tumor cells
- Adverse effects of chemoradiotherapy on invasion and metastasis of tumor cells
- Genes & Diseases 2020年7卷第3期
- 作者机构：
  
  1. The Department of Radiation Oncology, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University,Kunming,China
  2. Institute for Viral Hepatitis, The Second Affiliated Hospital of Chongqing Medical University,Chongqing,China
  3. Liver Cancer Institute and Zhongshan Hospital, Fudan University,Shanghai,China
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2020.04.004
  中图分类号：
- 纸质出版日期：2020，
  
  网络出版日期：2020-9-1，
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Wei Xiong, Yong Liao, Ji-Yong Qin, 等. Adverse effects of chemoradiotherapy on invasion and metastasis of tumor cells[J]. Genes & Diseases, 2020,7(3).

Wei Xiong, Yong Liao, Ji-Yong Qin, et al. Adverse effects of chemoradiotherapy on invasion and metastasis of tumor cells[J]. Genes & Diseases, 2020,7(3).
Wei Xiong, Yong Liao, Ji-Yong Qin, 等. Adverse effects of chemoradiotherapy on invasion and metastasis of tumor cells[J]. Genes & Diseases, 2020,7(3). DOI： 10.1016/j.gendis.2020.04.004.

Wei Xiong, Yong Liao, Ji-Yong Qin, et al. Adverse effects of chemoradiotherapy on invasion and metastasis of tumor cells[J]. Genes & Diseases, 2020,7(3). DOI： 10.1016/j.gendis.2020.04.004.

摘要

Abstract

The phenomenon of enhanced invasion and metastasis of residual tumor cells has been observed in an increasing number of patients receiving chemoradiotherapy recently

and tumor metastasis will undoubtedly limit patient prognosis. However

the key mechanism by which chemoradiotherapy affects the invasion and metastasis of tumor cells remains unclear. Studies have shown that chemoradiotherapy may directly act on tumor cells and alter the tumor microenvironment

or induce cell apoptosis and autophagy to promote tumor cell survival and metastasis. In this review

we summarize the potential mechanisms by which chemoradiotherapy may affect the biological behavior of tumor cells and open up new avenues for reducing tumor recurrence and metastasis after treatment. These insights will improve the efficacy of chemoradiotherapy.

关键词

Keywords

Biological behaviorCancerChemoradiotherapyMechanismInvasion and metastasis

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