The functions of N6-methyladenosine modification in lncRNAs

Rong-Zhang He; Jing Jiang; Di-Xian Luo

doi:10.1016/j.gendis.2020.03.005

您当前的位置：

首页 >

文章列表页 >

The functions of N6-methyladenosine modification in lncRNAs

Review article | 更新时间：2022-06-24

- The functions of N6-methyladenosine modification in lncRNAs
- The functions of N6-methyladenosine modification in lncRNAs
- Genes & Diseases 2020年7卷第4期
- 作者机构：
  
  1. Department of Clinical Pharmacology, Xiangya Hospital, Central South University,Hunan,Changsha,China,410078
  2. Translational Medicine Institute, National & Local Joint Engineering Laboratory for High-through Molecular Diagnosis Technology, Collaborative Research Center for Post-doctoral Mobile Stations of Central South University, Affiliated the First People's Hospital of Chenzhou, University of South China,Chenzhou,China,423000
  3. Center for Clinical Pathology, The First People's Hospital of Chenzhou, University of South China, Chenzhou, 423000, People's Republic of China
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2020.03.005
  中图分类号：
- 纸质出版日期：2020，
  
  网络出版日期：2020-12-1，
扫描看全文
Rong-Zhang He, Jing Jiang, Di-Xian Luo. The functions of N6-methyladenosine modification in lncRNAs[J]. Genes & Diseases, 2020,7(4).

Rong-Zhang He, Jing Jiang, Di-Xian Luo. The functions of N6-methyladenosine modification in lncRNAs[J]. Genes & Diseases, 2020,7(4).
Rong-Zhang He, Jing Jiang, Di-Xian Luo. The functions of N6-methyladenosine modification in lncRNAs[J]. Genes & Diseases, 2020,7(4). DOI： 10.1016/j.gendis.2020.03.005.

Rong-Zhang He, Jing Jiang, Di-Xian Luo. The functions of N6-methyladenosine modification in lncRNAs[J]. Genes & Diseases, 2020,7(4). DOI： 10.1016/j.gendis.2020.03.005.

摘要

Abstract

Increasing evidence indicates that mRNAs are often subject to posttranscriptional modifications. Among them

N6-methyladenosine (m6A)

which has been shown to play key roles in RNA splicing

stability

nuclear export

and translation

is the most abundant modification of RNA. Extensive studies of m6A modification of mRNAs have been carried out

while little is known about m6A modification of long non-coding RNAs (lncRNAs). Recently

several studies reported m6A modification of lncRNAs. In this review

we focus on these m6A-modified lncRNAs and discuss possible functions of m6A modification.

关键词

Keywords

ErasersLncRNAN6-methyladenosineReadersWriters

references

查看原文

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

Autophagy-related lncRNAs in tumor progression and drug resistance: A double-edged sword

RNA m⁶A reader YTHDF2 facilitates precursor miR-126 maturation to promote acute myeloid leukemia progression

Long noncoding RNA (lncRNA) H19: An essential developmental regulator with expanding roles in cancer, stem cell differentiation, and metabolic diseases

Studies on the fat mass and obesity-associated (FTO) gene and its impact on obesity-associated diseases

FTO-mediated m6A modification alleviates autoimmune uveitis by regulating microglia phenotypes via the GPC4/TLR4/NF-κB signaling axis