Does epigenetics have a role in age related macular degeneration and diabetic retinopathy?

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Does epigenetics have a role in age related macular degeneration and diabetic retinopathy?

Review article | 更新时间：2022-06-24

- Does epigenetics have a role in age related macular degeneration and diabetic retinopathy?
- Does epigenetics have a role in age related macular degeneration and diabetic retinopathy?
- Genes & Diseases 2021年8卷第3期
- 作者机构：
  
  1. SN ONGC Department of Genetics and Molecular Biology, Vision Research Foundation, Sankara Nethralaya, 41/18, College Road,Chennai,India,600006
  2. Department of Zoology, Avinashilingam Institute for Home Science and Higher Education for Women, Avinashilingam University for Women, Coimbatore, Tamil Nadu,India,641046
  3. Department of Biochemistry, Dr.N.G.P Arts and Science College, Coimbatore, Tamil Nadu,India,641046
  4. Human Molecular Genetics and Stem Cells Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore, Tamil Nadu,India,641046
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2020.01.003
  中图分类号：
- 纸质出版日期：2021，
  
  网络出版日期：2021-5-1，
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S. Mohana Devi, I. Mahalaxmi, J. Kaavya, 等. Does epigenetics have a role in age related macular degeneration and diabetic retinopathy?[J]. Genes & Diseases, 2021,8(3).

S. Mohana Devi, I. Mahalaxmi, J. Kaavya, et al. Does epigenetics have a role in age related macular degeneration and diabetic retinopathy?[J]. Genes & Diseases, 2021,8(3).
S. Mohana Devi, I. Mahalaxmi, J. Kaavya, 等. Does epigenetics have a role in age related macular degeneration and diabetic retinopathy?[J]. Genes & Diseases, 2021,8(3). DOI： 10.1016/j.gendis.2020.01.003.

S. Mohana Devi, I. Mahalaxmi, J. Kaavya, et al. Does epigenetics have a role in age related macular degeneration and diabetic retinopathy?[J]. Genes & Diseases, 2021,8(3). DOI： 10.1016/j.gendis.2020.01.003.

摘要

Abstract

Epigenetic mechanisms play an important part in the regulation of gene expression and these alterations may induce long-term changes in gene function and metabolism. They have received extensive attention in bridging the gap between environmental exposures and disease development via their influence on gene expression. DNA methylation is the earliest discovered epigenetic alteration. In this review

we try to examine the role of DNA methylation and histone modification in Age related macular degeneration (AMD) and Diabetic Retinopathy (DR)

its vascular complications and recent progress. Given the complex nature of AMD and DR

it is crucial to improve therapeutics which will greatly enhance the quality of life and reduce the burden for millions of patients living with these potentially blinding conditions.

关键词

Keywords

Age-related macular degeneration (AMD)Diabetic Retinopathy (DR)EpigeneticsGene expression

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