Immune checkpoint molecules: “new” kids on the block of skin photoimmunology

Wei Wang; Zhao-Hui Wu

doi:10.1016/j.gendis.2019.11.002

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Immune checkpoint molecules: “new” kids on the block of skin photoimmunology

Editorial | 更新时间：2022-06-24

- Immune checkpoint molecules: “new” kids on the block of skin photoimmunology
- Immune checkpoint molecules: “new” kids on the block of skin photoimmunology
- Genes & Diseases 2021年8卷第1期
- 作者机构：
  
  1. Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center,TN,Memphis,USA
  2. Center for Cancer Research, University of Tennessee Health Science Center,TN,Memphis,USA
  3. Department of Radiation Oncology,USA
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2019.11.002
  中图分类号：
- 纸质出版日期：2021，
  
  网络出版日期：2021-1-1，
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Wei Wang, Zhao-Hui Wu. Immune checkpoint molecules: “new” kids on the block of skin photoimmunology[J]. Genes & Diseases, 2021,8(1).

Wei Wang, Zhao-Hui Wu. Immune checkpoint molecules: “new” kids on the block of skin photoimmunology[J]. Genes & Diseases, 2021,8(1).
Wei Wang, Zhao-Hui Wu. Immune checkpoint molecules: “new” kids on the block of skin photoimmunology[J]. Genes & Diseases, 2021,8(1). DOI： 10.1016/j.gendis.2019.11.002.

Wei Wang, Zhao-Hui Wu. Immune checkpoint molecules: “new” kids on the block of skin photoimmunology[J]. Genes & Diseases, 2021,8(1). DOI： 10.1016/j.gendis.2019.11.002.

摘要

Abstract

Ultraviolet radiation (UVR) is a prominent etiological factor of the pathogenesis of skin diseases such as squamous cell carcinoma and melanoma. Excessive exposure to the natural sources of UVR such as sunlight or artificially from tanning lamps has been linked to the increasing incidence of skin cancers in the United States. Besides the skin inflammation

DNA damage and oncogenic mutation caused by UVR

UV exposure also plays a critical role in suppressing local and systemic immune responses which enable premalignant and cancer cells to escape immune surveillance. A variety of mechanisms have been reported to regulate the immune-suppressive effects of UVR. Here we discuss the current understanding of how UV modulates the local and systemic immunity

the recent progress in roles of immune checkpoint molecules in UVR-induced immune suppression

and how the crosstalk between the immune cells may shape the immune landscape of the skin upon UVR.

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