Alternative polyadenylation of mRNA and its role in cancer

Fuwen Yuan; William Hankey; Eric J. Wagner; Wei Li; Qianben Wang

doi:10.1016/j.gendis.2019.10.011

您当前的位置：

首页 >

文章列表页 >

Alternative polyadenylation of mRNA and its role in cancer

Review article | 更新时间：2022-06-24

- Alternative polyadenylation of mRNA and its role in cancer
- Alternative polyadenylation of mRNA and its role in cancer
- Genes & Diseases 2021年8卷第1期
- 作者机构：
  
  1. Department of Pathology, Duke University School of Medicine,NC,Durham,USA,27710
  2. Department of Biochemistry and Molecular Biology, University of Texas Medical Branch at Galveston,TX,Galveston,USA,77555
  3. Department of Biological Chemistry, University of California, Irvine,CA,USA,92697
  4. Duke Cancer Institute Center for Prostate and Urologic Cancers, Duke University School of Medicine,NC,Durham,USA,27710
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2019.10.011
  中图分类号：
- 纸质出版日期：2021，
  
  网络出版日期：2021-1-1，
扫描看全文
Fuwen Yuan, William Hankey, Eric J. Wagner, 等. Alternative polyadenylation of mRNA and its role in cancer[J]. Genes & Diseases, 2021,8(1).

Fuwen Yuan, William Hankey, Eric J. Wagner, et al. Alternative polyadenylation of mRNA and its role in cancer[J]. Genes & Diseases, 2021,8(1).
Fuwen Yuan, William Hankey, Eric J. Wagner, 等. Alternative polyadenylation of mRNA and its role in cancer[J]. Genes & Diseases, 2021,8(1). DOI： 10.1016/j.gendis.2019.10.011.

Fuwen Yuan, William Hankey, Eric J. Wagner, et al. Alternative polyadenylation of mRNA and its role in cancer[J]. Genes & Diseases, 2021,8(1). DOI： 10.1016/j.gendis.2019.10.011.

摘要

Abstract

lternative polyadenylation (APA) is a molecular process that generates diversity at the 3′ end of RNA polymerase II transcripts from over 60% of human genes. APA is derived from the existence of multiple polyadenylation signals (PAS) within the same transcript

and results in the differential inclusion of sequence information at the 3′ end. While APA can occur between two PASs allowing for generation of transcripts with distinct coding potential from a single gene

most APA occurs within the untranslated region (3′UTR) and changes the length and content of these non-coding sequences. APA within the 3′UTR can have tremendous impact on its regulatory potential of the mRNA through a variety of mechanisms

and indeed this layer of gene expression regulation has profound impact on processes vital to cell growth and development. Recent studies have particularly highlighted the importance of APA dysregulation in cancer onset and progression. Here

we review the current knowledge of APA and its impacts on mRNA stability

translation

localization and protein localization. We also discuss the implications of APA dysregulation in cancer research and therapy.

关键词

Keywords

3′ untranslated regionAlternative polyadenylationCancerGene regulationPolyadenylation signals

references

查看原文

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

De novo nucleotide biosynthetic pathway and cancer

Multiple regulatory roles of the transfer RNA-derived small RNAs in cancers

The generation and use of animal models of osteosarcoma in cancer research

The evolving roles of Wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities

Synthetic lethal approaches to target cancers with loss of PTEN function