Obesity as potential breast cancer risk factor for postmenopausal women

Swati Sucharita Mohanty; Prafulla Kumar Mohanty

doi:10.1016/j.gendis.2019.09.006

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Obesity as potential breast cancer risk factor for postmenopausal women

Review article | 更新时间：2022-06-24

- Obesity as potential breast cancer risk factor for postmenopausal women
- Obesity as potential breast cancer risk factor for postmenopausal women
- Genes & Diseases 2021年8卷第2期
- 作者机构：
  
  Cytogenetics Laboratory, P.G. Department of Zoology, Utkal University, Bhubaneswar, 751004, Odisha,India
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2019.09.006
  中图分类号：
- 纸质出版日期：2021，
  
  网络出版日期：2021-3-1，
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Swati Sucharita Mohanty, Prafulla Kumar Mohanty. Obesity as potential breast cancer risk factor for postmenopausal women[J]. Genes & Diseases, 2021,8(2).

Swati Sucharita Mohanty, Prafulla Kumar Mohanty. Obesity as potential breast cancer risk factor for postmenopausal women[J]. Genes & Diseases, 2021,8(2).
Swati Sucharita Mohanty, Prafulla Kumar Mohanty. Obesity as potential breast cancer risk factor for postmenopausal women[J]. Genes & Diseases, 2021,8(2). DOI： 10.1016/j.gendis.2019.09.006.

Swati Sucharita Mohanty, Prafulla Kumar Mohanty. Obesity as potential breast cancer risk factor for postmenopausal women[J]. Genes & Diseases, 2021,8(2). DOI： 10.1016/j.gendis.2019.09.006.

摘要

Abstract

Breast cancer is the second highest prevalent cancer globally after lung cancer with 2.09 million cases during 2018. Adults about 1.9 billion were overweight and over 650 million out of these were obese during 2016. There is a significant relationship between breast cancer risk and obesity. Premature menopause and premenopausal obesity diminish the risk whereas postmenopausal obesity amplifies the risk

because adipose tissue acts as the major reservoir for estrogen biosynthesis after menopause. Lofty estrogen levels in serum along with enhanced peripheral site production of estrogen have been viewed as major reasons of developing breast cancer in overweight postmenopausal women. This review explains body fat as a peripheral site for estrogen biosynthesis

estrogen exposure affecting body fat distribution

and the mechanism of estrogen production from body fats.

关键词

Keywords

AdipocyteAromataseBreast cancerEstrogenObesity

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