Unique and independent role of the GABAB1 subunit in embryo implantation and uterine decidualization in mice

Wenhao Chen; Qian Zhang; Haibin Wang; Dongmei Tan; Yi Tan

doi:10.1016/j.gendis.2019.06.005

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Unique and independent role of the GABAB1 subunit in embryo implantation and uterine decidualization in mice

Full-length article | 更新时间：2022-06-24

- Unique and independent role of the GABAB1 subunit in embryo implantation and uterine decidualization in mice
- Unique and independent role of the GABAB1 subunit in embryo implantation and uterine decidualization in mice
- Genes & Diseases 2021年8卷第1期
- 作者机构：
  
  1. Laboratory Animal Center, Chongqing Medical University,Chongqing,PR China,400016
  2. Reproductive Medical Center, The First Affiliated Hospital of Xiamen University,Fujian,Xiamen,PR China,361003
  3. Fujian Provincial Key Laboratory of Reproductive Health Research, Medical College of Xiamen University,Fujian,Xiamen,PR China,361102
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2019.06.005
  中图分类号：
- 纸质出版日期：2021，
  
  网络出版日期：2021-1-1，
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Wenhao Chen, Qian Zhang, Haibin Wang, 等. Unique and independent role of the GABAB1 subunit in embryo implantation and uterine decidualization in mice[J]. Genes & Diseases, 2021,8(1).

Wenhao Chen, Qian Zhang, Haibin Wang, et al. Unique and independent role of the GABAB1 subunit in embryo implantation and uterine decidualization in mice[J]. Genes & Diseases, 2021,8(1).
Wenhao Chen, Qian Zhang, Haibin Wang, 等. Unique and independent role of the GABAB1 subunit in embryo implantation and uterine decidualization in mice[J]. Genes & Diseases, 2021,8(1). DOI： 10.1016/j.gendis.2019.06.005.

Wenhao Chen, Qian Zhang, Haibin Wang, et al. Unique and independent role of the GABAB1 subunit in embryo implantation and uterine decidualization in mice[J]. Genes & Diseases, 2021,8(1). DOI： 10.1016/j.gendis.2019.06.005.

摘要

Abstract

Embryo implantation and decidualization are crucial for successful pregnancy

which include multiple genes and signaling pathways

while the precise mechanism regarding embryo implantation and decidualization has yet to be explored. The GABA which activates GABA

or GABA

receptors has been found playing an important role in early pregnancy. Here we seek to investigate whether GABA

receptors participate in embryo implantation in mice. This study first characterized the spatiotemporal expression pattern of GABA

receptors in the uterus during the peri-implantation period and found that GABA

expression was drastically upregulated in stromal cells on days 4–6

a period of embryo implantation and early stages of decidualization. Embryo delayed implantation and oil-induced decidualization models were further used to confirm that the GABA

was associated with embryo implantation and decidualization. We also found estrogen or progesterone had no directly effect on expression of GABA

in ovariectomized model. Because we were unable to detect significant GABA

which couples with GABA

to form whole GABA

receptors

and the agonist and antagonist of whole GABA

receptors had weak effect on the proliferation and differentiation of stromal cells as well

we excluded the possibility whole GABA

receptors function

and concluded it should be non-classical signals of GABA

involving in embryo implantation and decidualization. Future studies should focus on investigating the roles and mechanisms of GABA

during embryo implantation and decidualization.

关键词

Keywords

DecidualizationEmbryo implantationEndometrial stromal cellsGABAB1Ovarian hormonesProliferation

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