The teaching reform of education methods and course contents was carried out for sev-en-year program medical students in clinical neurology courses. Case-based instruction method， evidence based medicine and standardized patient were flexibly applied， case discussion mode and multimedia teaching were added， and humanistic education was merged into teaching process. The enthusiasm and creativity of students were fully activated through the comprehensive application of various teaching methods， and the teaching quality of neurology course was improved， and the purpose of comprehensive quality education for the culture of long-year program medical students was better achieved.