This paper reviewed and analyzed the whole 29 years' compiling and revising histo-ry of Neurology the 5-year programming textbook for national undergraduates. The textbook has been becoming a high-quality textbook with novelty， practicability， readability and systematicness， conform-ing to the need of national education reform and reflecting the characteristics of neurology. Through the review of textbook history， we know that material construction can deepen the educational reform， improve the teaching level and discipline development， promote quality education and personnel train-ing.