Targeting to improve clinical thinking and practice skill of interns， modified Team-based learning （TBL） based on seeing real patient was performed for interns from eight-year clinical medicine program. Teachers prepared the corresponding case material before the teaching and made teaching aids. And interns were mobilized and guided to preview and self-study in teams. During modi-fied TBL， in-class application of seeing real patient was performed to assess the effect of self-study in teams， besides individual test and team test deriving from traditional TBL. All teams were assigned one task of seeing real patient by drawing lots， and then finished the task， answered teachers' questions. And the students' performance was given comments and comprehensive scores by the judges. After the completion of teaching， the teaching effectiveness of the modified TBL was assessed from students' performance， their scores and their teaching evaluation. Practice shows that the modified TBL can not only attract students to engage in it， but also elevate their abilities of clinical thinking and practical skill. It can also cultivate their interpersonal ability.