Objective　This article made an exploration on the feasibility of combined applica-tion of TBL with LBL in immunology experiment teaching， and analyzed teaching effectiveness of such combined model in order to find a new way of teaching reformation. Methods　2012 grade biophar-maceutical technology students were chosen in this research， one class as the experimental group（n=42）， the other one as control group（n=42）. In the experimental group， students were taught on a TBL+LBL combination model， while in the control group， students were taught only on LBL model. After the course was finished， effects of teaching were evaluated by questionnaire survey and compre-hensive ability evaluation. SPSS 18.0 software was used to do statistical analysis. Quantitative data and qualitative data were analyzed by t test and chi-square test respectively. P<0.05 means that difference is statistically significant. Results　Above 90.0% of students in experiment group approved that TBL+LBL can improve the interest in learning， can enhance sense of teamwork， can help acquiring of knowledge and improving of individual comprehensive ability. Average score of comprehensive ability evaluation and percentage of students achieving good score in experimental group were higher than those in control group， the differences were statistically significant（t=2.020， P=0.049； ?字2=6.372， P=0.012）. Conclusion　The TBL +LBL combination model can improve immunology experiment teach-ing quality， and is worth publicizing.