Objective　To investigate the effect of the complementary matching character teaching model in clinical infectious department nursing teaching and improve the effect of nursing teaching. Methods　164 student nurses in our hospital from June 2010 to May 2011 were selected and they were randomly divided into the experimental group（37 nurses） and the control group（127 nurses）. Besides， the experimental group was divided into introverts（60 nurses） and extroverts（70 nurses） according to the 16 personality factor test scale. The traditional nursing teaching mode was adopted in the control group while in the experimental group complementary matching character teaching model was applied， including four groups： outgoing teachers for introverted students， outgoing teachers for outgoing students， introverted teachers for outgoing students and introverted teachers for introverted students. After two months of training， all the nurses were requested to take a closed book examination and the data of the examination scores and the students' evaluation were analyzed as the teaching effect evaluation by using SPSS 19.0 and the counting data by ?字2 inspection， the measurement data by single factor analysis of variance and the test level of α=0.05（bilateral）. Results　The final evalua-tion results of control group and the group of introverted teacher for introverted students are significantly lower than those of other groups（P<0.05）. Conclusion　The complementary matching character teaching method has more advantages than the traditional one， but the matching of introverted teacher and introverted students should be avoided. The interaction of teachers and students should be given full play to improve the quality of practice nurse teaching.