Objective To investigate the application and effect of blended learning in epidemiology course. Methods　The 83 nursing undergraduates in one class of grade 2016 were enrolled as experimental group and the 122 nursing undergraduates in another class were enrolled as control group. The undergraduates in the experimental group received blended learning in epidemiology course

and those in the control group received traditional teaching. An anonymous questionnaire survey was performed after the course ended

and the teaching effect was assessed based on the score of a non-standard answer examination and the degree of recognition of comprehensive ability cultivation. SPSS 18.0 was used for data analysis

and the t-test and the chi-square test were used for comparison of data between groups. Results　The experimental group had a significantly higher total score than the control group [(85.55±10.49) vs.( 80.07±9.47)

t=3.897

P=0.000]. Compared with the control group

the experimental group had a significantly higher degree of recognition of independent learning ability

cooperative ability

knowledge application

and problem-solving ability after blended learning (P<0.05). Conclusion　Blended learning can be applied in epidemiology course

and its teaching effect is accepted by students.