Objective　To investigate the application of 3D printing in the flipped classroom in the practice teaching of otolaryngology-head and neck surgery. Methods　A total of 68 medical undergraduates of the Grade 2013 in Air Force Medical University were divided into experimental group and control group

with 34 undergraduates in each group. The undergraduates in the experimental group received the teaching method of 3D printing in the with flipped classroom

and those in the control group received traditional teaching. The teaching effect was evaluated by questionnaire and examinations of basic knowledge and clinical skills

Independent-samples t test was used for between-group comparison with SPSS 20.0. Results　Compared with the control group

the experimental group had significantly higher scores in theoretical examinations (34.79±2.20 vs. 31.73±3.12

t=4.676

P=0.000) and clinical skill examination (50.06±2.98 vs. 45.82±4.68

t=4.449

P=0.000). The questionnaire survey showed that among the 34 undergraduates in the experimental group

31(91.2%) thought that the new teaching method could increase their learning interest

33(97.0%) believed it could improve learning efficiency

25(73.5%) believed the models obtained by 3D printing had good quality

32(94.1%) felt that it could improve clinical skills

28 (82.4%) thought it could enhance the interaction between students and teachers

and 29(85.3%) thought it did not bring extra burden. Conclusion　The teaching method of 3D printing combined with flipped classroom in the practice teaching of otolaryngology-head and neck surgery can improve students' learning interest

academic scores

and clinical skills

and therefore

it holds promise for application in teaching.