【Abstract】： Objective To find out the effets of the teaching mode of “Micro-course” combined with “Simbaby” in neonatal undergraduate practice teaching. Methods Totally 160 five-year clinical medical undergraduate students of 2013 grade to 2015 grade were divided into two groups： A （control group）and B （experimental group）

including 40 male students and 40 female students. The students in B group were received the ML+Simbaby teaching method while those in A group were received traditional teaching method.In A Group

at fist the teachers teach the knowledge

and applies ordinary molds for demonstration teaching.Finally，the students doing imitateion exercises. In B Group

the students will prepare for the class though the “micro-course”

while the teachers will make Simbaby simulation case models and explain how to use it.Then

the students will make diagnosis and treatment after the physical examination of the Simbaby.Teaching effectiveness Was evaluated by questionnaire survey and theoretical test. Results The average score of the theoretical test in the B group (88.40±9.40) and the average score in the skill test (79.53±8.84) were significantly higher than that of the A group (84.86±9.50；72.35±9.70).and difference were statistically significant (P<0.05). The questionnaire showed that the learning enthusiasm and initiative

clinical operation skills and clinical thinking ability were significantly better in B group than in the A group(P<0.05). However

there was no significant difference between the two groups in improving team awareness(P>0.05). Conclusion The teaching mode of Micro-course combined with Simbaby is helpful to grasp basic theoretical knowledge and improve clinical operation skills of neonatal diseases

while it can improve self-learning ability and exercise clinical thinking ability. It is worthy of promotion in neonatal clinical teaching.