Objective　To investigate the application value of real clinical case centered situation simulation examination model in clinical medicine. Methods　Two classes were randomly selected from 2008 grade clinical medicine majors， respectively as test group（n=158） and control group（n=156）. Final examination of test group includes usual performance， case-oriented situation simulation examination （COSSE） and final written examination. Traditional methods were used in control group. The same paper was used in final written examination of the two groups. Scores of written examination and question-naires were used to evaluate the COSSE model. Data were processed using SPSS 16.0 statistical software； t and chi-square tests were used to analyze the data； P<0.05 signifies that the difference is statistically sig-nificant. Results　Scores of final examination in test group were higher than those in control group（P＜0.001）. Times of independent completion of history taking， physical examinations and medical record writing were more in test group than in control group（P=0.002，0.017，0.048）. Conclusions　Contents and methods of COSSE is conducive to improving student's professional comprehensive ability.