Mobile learning has the characteristics of mobility， timeliness， network and virtu-ality. We developed virtual hospital suitable for mobile devices and organized students in to a network. Through early training， clinical case screen， learning objective fix， learning process and results evaluation， mobile devices were employed to do problem-based learning， which is conducive to the integration of theory with practice， the shifting from discipline-centered to system-based courses and the improving of utilization rate of learning resource.