Objective　To investigate the application effect of the new trinity teaching mode of clinical practice， which combines bedside teaching， simulation teaching and web-based teaching to-gether. Methods　Totally 375 students of clinical medicine， enrolled into Guangzhou Medical Univer-sity in 2006， were randomly divided into department I of clinical medicine （control group， 188 stu-dents） and department II of clinical medicine （experimental group， 187 students）. The students of these two groups were taught respectively with the conventional bedside teaching mode and the trinity teaching mode. Then at the end of clinical practice， assessment results of comprehensive theory and clinical skill in the graduation exam were compared by t test （significance level α=0.05） using SPSS 17.0 software and the questionnaire results of students in experimental group were analyzed. Results There were statistical differences in comprehensive theory and clinical skill assessment scores between two groups（P＜0.05）. The questionnaire survey showed an approval rate of 92.73%（153/165） for trini-ty teaching mode. Conclusions　Facing the shortage of clinical teaching resources， the trinity teach-ing mode is better than the simple bedside teaching mode. The trinity teaching mode can alleviate the pressure brought by the lack of clinical teaching resources at present， create more learning and prac-ticing opportunities for students， and improve the effects of clinical practice teaching.