Objective　To explore the application effect of sandwich teaching method in clini-cal teaching in the department of orthopedics. Methods　Totally 150 clinical medicine students were divided into 2 groups： sandwich teaching group （n=75） and lecture-based learning group（n=75）. Sandwich teaching method combined with bedside teaching method was used in sandwich teaching group while lecturing combined with bedside teaching method was used in control group. Theoretical examination， clinical operation skill test， clinical case analysis and questionnaire investigation were conducted after the course. Comparison between the two groups was made using independent sample t test and measurement data were expressed as x±s. P<0.05 signifies statistically significant differences. Results　Theoretical examination score， clinical skill test score and clinical case analysis score were higher in sandwich teaching group than in control group. [（53.70±4.27） vs. （48.00±4.83）；（15.70±2.49） vs. （11.40±2.87）；（17.10±1.52） vs. （13.80±1.32）]. Questionnaire showed that commutation and expression ability， cooperation ability and self thinking ability were better in sandwich teaching group than in control group， with statistical differences. Conclusions　Sandwich teaching method achieves good teaching effect and it is worth recommending in clinical teaching．