Taking global minimum essential requirements（GMER） as standard， school of basic medical science in Wuhan University paid more attention to the cultivation of students' professional skills， innovation ability and communication ability. ‘Response to injury’ integrated course was carried out. Based on the immunology， this course involves pathology and pathophysiology and explores the mecha-nism of the diseases' diagnosis and treatment. It took small classes， bilingual education， literature read-ing， experiments and discussions in various forms. This reform aimed to improve the immunology， pathology and pathophysiology teaching and make our medical education meet the process of globalization.