Case-based teaching （CBT） on the basis of treatment guidelines was carried out to develop standard medical behavior， improve learning efficiency and students' ability of solving clini-cal problems. In clinical internship teaching， guidelines for common and frequently-occurring respira-tory diseases and CBT were organically combined. Cases were carefully selected and questions were meticulously set. Guidelines were thoroughly analyzed and teaching was reasonably evaluated. There-fore， students' learning interests were initiated and learning efficiency was improved. It not only trained evidence-based medicine thinking of intern students， but also improved the teaching ability of clinical teachers.