To improve the quality of medical postgraduate students in our school and to meet the needs of basic medicine and the development of personalized medicine， we opened the course “molecular pathology” to medical graduates. To make the molecular pathology the true bridge course between basic medicine and clinical medicine， we optimized the content of molecular pathology， cre-ated diagnostic technical platform matched with molecular pathology， rationalized management system worked in the basic pathology and clinical pathology. Practice has proved that “molecular pathology” curriculum promotes medical postgraduate students' transformation of medical philosophy， cultivates their innovation ability in scientific research and clinical practice ability etc.