Objective: To compare the application effect between problem-based learning (PBL) and traditional teaching in cardiovascular intervention. Methods:39 postgraduate doctors were divided randomly into the PBL group( n = 20) and control group(n=19),the effects of teaching were evaluated by examination and questionnaire. Results:PBL group's scores of operational skills exams (30.07±1.67vs28.54±1.98,P=0.036)and comprehensive analysis(34.47±1.77vs32.08±1.80,P=0.002) were all higher than those of the control group(P< 0.05).The PBL group's satisfaction evaluation was higher than that of conventional group(P<0.05).Conclusion:PBL can better stimulate students'initiative to learn and achieve better results.