Objective To observe and investigate the effects of the case-based learning assisted with WeChat software in the lesson of Nursing constitution regulating theory. Method The two classes of nursing undergraduate grade 2013 were randomized into the Case-Based Learning (CBL) group and the traditional teaching group (LBL). WeChat combined with CBL group of preparation before class

the teacher write cases and to consider

WeChat sending teaching information

such as student group discussion

collect data

etc.)

mainly students speaking class

the teacher to do review

summarize and scoring; Teacher prepares a lesson

multimedia PPT teaching LBL group. We used the test of Nursing constitution regulating and teaching effect questionnaire to compare the differences between the two groups. Results The single choice score

multiple choice score and the total score of the test of Nursing constitution regulating in the CBL group were 52.46±4.35

33.42±3.1

and 85.88±5.72

higher than the LBL group which were 47.63±5.84

29.88±4.55

and 77.50±7.88. The difference was statistically significant (P＜0.05). Scores of self-study ability

interest in learning

literature retrieval ability

communication and cooperation ability

TCM differentiation and the examination scores in CBL group were significantly higher than that in LBL group（P＜0.05). Conclusion The case-based learning assisted with WeChat software could inspire the interest of learning

cultivate the self-study ability and practice the ability of TCM differentiation. It is worthy of being generalized.