To design teaching course of problem-based learning (PBL) combined with case-based learning (CBL) for standardized training of clinicians based on clinical decision thinking mode (CDTM) of diagnosis and treatment process for primary liver cancer. The CDTM of treatment choice for primary liver cancer is multi-scheme selection model. The general decision rule includes decision condition

action plan and decision tree. It is suitable to design PBL teaching course for theoretical study of clinical decision rules

but to design CBL teaching course for clinical decision practice. The teaching course of PBL combined with CBL is conducive to improve the ability of clinicians’ clinical decision thinking step by step.