Objective To explore the application of team-based learning (TBL) and problem-based learning (PBL) method in clinical teaching of laparoscopic surgery in general surgery．Methods 48 students of surgery in our department were selected as the subjects to conduct the clinical teaching study. These students were divided randomly into two groups. The experimental group (24 students) adopted the method that combined TBL and PBL method，and the control group (24 students) adopted the traditional teaching method. We compare the efficacy of two groups in term of theoretical knowledge

surgical practice

comprehensive surgical grade

and questionnaire survey. Results The score of theoretical knowledge and surgical practice on clipping soybean and making suturation and instrumental tie of two groups were obviously higher than that before teaching. After finishing teaching

the score of experimental group on theoretical knowledge

making suturation and instrumental tie and comprehensive surgical grade were higher than that of control group (P<0.05). The score of clipping soybean was similar between two group (P>0. 05). In addition

in term of questionnaire survey on the consciousness of independent study

the depth and width of study

and satisfactions to teaching

the TBL and PBL group have a better score than the control group. Conclusions The new teaching method which combined TBL with PBL enhances the teaching effect on theoretical knowledge and laparoscopic surgery practice. It is an effective method to train medical students．