[ Abstract ] Objective To explore the application effects of blending learning mode which is based on SPOC in preventive medicine teaching. Methods 92 students of 2013 grade

who major in medical imaging

were divided into two classes. 47students in the first class adopted LBL teaching method. Another class was experimental group

teaching the remained 45 students by blending learning mode which is based on SPOC method. Analyses and assessments were done by course examinations and questionnaires. Results The experimental groups are better than the control groups not only in the average score of synthetic scores（t=5.068

P=0.000）but also in the 80～89 and 90～100 number distribution (Z=3.713

P=0.000). 72.6％students of the experimental group accepts blending learning mode which is based on SPOC

which is revealed by the questionnaires. Conclusion: Ability about explorative thinking

independent learning and effect of teaching can be achieved by blending learning model which is based on SPOC.