The content of optical isomerism is the difficult point of organic chemistry teaching

and so CBL(Case-Based Learning)，theoretical-experimental integration teaching method and micro class teaching methods are tried to be used in classroom teaching according to the actual teaching situations. For CBL teaching method

the course is guided by the step of introduction-question- discussion and summary-extensions; For theoretical-experimental integration teaching method

combined with the theory class

the two experiments including the determination of optical rotation and organic molecular model are set for the optical isomer content

to enhance the students' understanding of theoretical knowledge through the hands-on operation; For micro class teaching method

the key and difficult points of this chapter are digged out and about 10 minutes of video are recorded by using common video software before class

which are introduced in the classroom or provided to students after class for repeated watching

to deepen the students’ understanding of the concept and phenomenon of optical isomers. In brief

it is important to combine various teaching method to improve the classroom instructing effectively and stimulate the students’ interest in organic chemistry.