Bioinformatics is an intercross field of biology and computer science. With the development of computer network information technology and “precision medical care”

biomedical field ushered in the era of big data. The demand for bioinformatics knowledge to medical students has shifted from single gene level to the analysis on massive medical data. This paper analyzed the characteristics of the big data era

as well as the problems of the teaching idea

curriculum coverage and teaching platform could not meet the requirements of the new era in teaching of bioinformatics course for medical students. Finally

we proposed several measures to strengthen the reform of bioinformatics teaching to meet the challenge of the big data era

including optimizing courses

changing educational philosophy

introducing new teaching methods

and setting up teaching platform with times.