Objective To explore the practical characteristic of Innovation and Creative Thinking course integrated with Challenge Based Learning (CBL). Methods Flanders Interaction Analysis System is used to analyze the class interaction of the Key Concept in Problem Framing. Result It was showed that the class with open free and safe environment. Students were the center and involved in the class highly. Conclusion Innovation and Creative Thinking course was helpful to nurture the ability to innovate and create among nursing students. The practical characteristic of this course will provide new ways to improve the innovativeness and creative thinking

which also will support the promotion of CBL in Chinese mainland.