Objective　To discuss the application of blending learning based on MOOC in Histology and Embryology

so as to improve students' learning effectiveness. Methods　Nursing undergraduates in class one of 2017 grade were randomly selected as experimental group (n=47)

and nursing undergraduates in class two as control group (n=48)

with blending learning and traditional teaching model adopted

respec-tively. SPSS 19.0 was applied to processing the data and T test were used to compare the results of the final exam of this course and the evaluation scale of students' independent learning ability in two groups. Results The experimental scores [(24.22±5.08) vs. (18.49±4.65)]

paper test scores [(52.37±6.24) vs. (47.15±5.99)]

and total score [(76.61±7.22) vs. (62.83±7.36)]

which shows the scores of experimental group were statistically higher than those of the control group. According to the evaluation scale of students' inde-pendent learning ability

the self-learning ability of the experimental group was better than that of the control group

with significant differences (P<0.05). Conclusion　Blending learning can be applied to the teaching of Histology and Embryology

which can effectively improve learning quality

with satisfactory teaching effects to both teachers and students.