Objective　To determine the effects and advantage of PBL teaching method combined with LBL teaching method over LBL teaching method. Methods　The interns from Department of Clinical Laboratory were selected as teaching subjects. Fifty interns were assigned randomly into two groups

25 in PBL+LBL group

25 in LBL group. After the designed teaching

the exam scores and satisfaction question-naire was evaluated. All the data was analyzed with SPSS 22.0. Counting data was analyzed with Chi-square

Fisher test because of smaller number. Results　In the exam test

the scores in PBL+LBL teaching group were significantly higher than that in the LBL group [(84.40±5.14) vs. (78.72±6.51)]. In the questionnaires

the satisfaction rate in the PBL+LBL group was also higher than that in the LBL group. The PBL+LBL teach-ing is helpful for improving the self-learning and collabora-tion ability of the students. Conclusion　PLB+LBL teaching method in tumor diagnosis showed improved teaching effects and higher satisfaction rate.