Objective　To investigate the effect of flipped classroom based on WeChat and mi-crolecture in medical chemistry experiment course in the context of internet. Methods　The classes were randomly divided into 2 groups

experimental group (flipped classroom teaching

n=97) and the control group (traditional teaching

n=98). Comparison of the chemistry experiment test results were performed with the use of t test between the two teaching groups at the end of the semester to evaluate the experimental teaching method. All statistical processing and analyses were performed with SPSS software (version 12.0). Results　The chemistry experiment test score of the experimental group was higher than that of the control group [(77.84±8.22) vs. (73.43±10.14)

t=3.341

P=0.008)

and the difference was statistically significant. The results of the questionnaire showed that the students in the experimental group generally consider that flipped classroom teaching is better than the traditional teaching in terms of the cultivation of comprehen-sive quality and the teaching effect. Conclusion　In the context of internet

flipped classroom teaching with WeChat microlecture can better mobilize the enthusiasm of students to learn and participate in medical chemistry experiment course

which has been welcomed by students and further suggest good application prospects.