Objective　To analyze the relationship between general gelf-efficacy and life-long learn-ing orientation in medical students of a university for providing scientific evidence for the improvement of their life-long learning orientation. Methods　In March 2015

all the fifth grade medical students

altogether 822

were invited to participate in the survey and 748 questionnaires were collected effectively. The instru-ments employed were General Self-efficacy Scale (GSES) and Jefferson Scale of Physician Life-Long Learning Student Version in Chinese (JSPLL-S). The relationship was analyzed by using multiple linear regression. Results　The general self-efficacy and life-long learning orientation in medical students had significantly positive correlation ( ?茁＝0.53，Ｐ=0.00). Furthermore the general self-efficacy was significantly correlated with each sub-domain of life-long learning orientation

specifically attention to learning opportunity ( ?茁＝0.53，Ｐ=0.00)

technical skills in information seeking ( ?茁＝0.47，Ｐ=0.00) and learning beliefs and motivation ( ?茁＝0.31，Ｐ=0.00) respectively. The results also indicated that the magnitude and significance of these corre-lations were independent from the individual characteristics. Conclusion　Medical students' general self-efficacy greatly affects their life-long learning orientation. Thus

the strategy aiming at improving students' general self-efficacy could be affective for the development of life-long learning orientation.