Objective To explore the application and effect of SPOC platform in medical immunol-ogy teaching. Methods The teaching reform class of Grade 2015 (41students) of Changzhi Medical College was taken as the experimental group

while the parallel class of imaging (37 students)

preventive specialty(40 students)

Class Nine of clinical medicine (37 students) and oral specialty (39 students) were randomly selected as the control group. SPOC learning platform + traditional teaching method was used for teach-ing and learning in the course of the test group. The traditional teaching method was utilized in the control one. For this type of teaching activity

a questionnaire survey was carried out among the students in the reform class

and the final exam score was used as the measure standard. The data were analyzed by SPSS 17.0 software. Results The results demonstrated that the students preferred to learn on the SPOC platform for mobile phones

and the number was significantly higher than that of learning through the computers. Students in the reform class basically liked this type of learning

and their final exam scores were more significant difference than the other classes in the same grade (t'=15.21

P=0.000). The classes in the experimental group and the control group were taken as the research objects

and the rank-sum test was performed

which was statistically significant ( ?字2=81.65

P=0.000). Then

the two groups were compared in different classes: the statistical difference between the teaching reform class and image 1502 (t'=11.52

P=0.000)

prevention 1502 (t'=7.38

P=0.000)

clinical medicine 1509 (t'=8.93

P=0.000)

oral 1501 class (t'=8.93

P=0.000) were found. The questionnaire survey demonstrated that 90.24% (37 students) of the reform class liked this form of learning and at the same time

it was suggested that the learning content on the platform should be further linked to the clinical practice and combined with scientific research to expand the students' thinking. Conclusion The SPOC learning platform has turned over the teaching of medical immunology and improved students' motivation and interests in learning.