Objective　To investigate the effectiveness of practice-oriented instruction in non-class-room learning on medical students' ability of medical translation. Methods　Two classes of Grade 2015 in School of Pharmacy were randomly divided into the experimental group (EG) and the control group (CG). EG (60 students) received traditional college English teaching added by practice-oriented instruction in non-classroom learning for medical translation

while CG (58 students) received only traditional college English teaching. One year later

analyses and assessments were done by course tests and questionnaires. Specifi-cally

the statistical analysis was done by SPSS 19.0

course tests analysis by t test and satisfaction investi-gation by Chi-square test. Results　EG showed more desirable effects than CG not only in the course test [(29.28±7.02) vs. (22.08±9.49)] （t=3.049，P=0.000）

but also in its positive attitude towards mode of teaching

class participation and problem-solving skills. Conclusion　Well-planned practice-oriented in-struction in non-classroom learning can improve medical students' ability of medical translation.