【Abstract】 Objective To evaluate the effects of comprehensive reform of clinical education on cultivating the clinical thinking ability of medical students in internal medicine. Methods A total of 44 clinical interns on medicine rotation were included in this study

and a series of co-ordinate measures in reform of clinical teaching

which included the undergraduate tutorial system

team-based learning (TBL) mode

combination of electronic medical record and handwritten medical record

as well as formative assessment

were applied to fully promote the clinical thinking ability of medical students.SPSS 17.0 software was used to compare the scores of the final academic subjects examination of rotation and competition of medical record writing between the control and the experiment groups.Self-designed questionnaires on undergraduate tutors and clinical interns were applied to comprehensively evaluate the effects of education reform. Results Independent-sample t tests showed there were statistically significant difference （P < 0.0001）in the scores of the final academic subjects examination of rotation and competition of medical record writing between the two groups

and the mean score of the experiment group was higher than that of the control group. Questionnaire survey showed that tutors and clinical interns fully affirmed the positive effects of the educational reform on cultivating the clinical thinking ability of medical students in internal medicine. Conclusion Application of comprehensive educational reform in clinical teaching of internal medicine

which based on introduction of undergraduate tutorial system and TBL mode

could effectively promote the clinical thinking ability of medical students and the teaching quality.