Objective　To explore the effect of self-learning ability and critical thinking ability in nursing students under mobile teaching mode based on portable classroom platform. Methods　Two classes of batch 2015 from nursing college were randomly selected and divided into control group (n=58) and experimental group (n=61). The control group adopted conventional teaching mode

while the experimental group used the same mode in addition to mobile teaching mode based on portable classroom platform. Self-learning ability questionnaire and critical thinking ability scale in Chinese were used to evaluate the teaching effect

and t test was performed to analyze the data using SPSS 19.0. Results　After intervention

scores of different items and the total scores in the self-learning ability scale in the experimental group were higher than those in the control group

with statistical significance (P<0.05); scores of different items and the total scores in the critical thinking ability questionnaire in the experimental group were higher than those in the control group

with statistical significance (P<0.05). Conclusion　Mobile teaching mode based on portable classroom platform can improve the self-learning ability and critical thinking ability of nursing students.