Objective　To explore the application and effect of the online teaching in the clinical nursing practice of obstetrics and gynecology during the coronavirus disease 2019 (COVID-19) epidemic. Methods　A total of 26 undergraduate nursing interns in the obstetrics and gynecology department of Xiangya Hospital of Central South University during the epidemic period were enrolled in this study. The interns accepted online practical teaching

and the teaching effect was analyzed and evaluated through the results of the exit examination and online teaching satisfaction. Results　The theoretical course scores of nursing students are all above 80 points

among which 22 (84.62%) are above 90 points. The operation scores are all above 90 (94.04±2.96) points. The results of the online teaching satisfaction survey show that

23 (88.46%) nursing students are satisfied with the effect of their online practice. Conclusion　The online teaching mode during COVID-19 epidemic can help nursing students master the theoretical knowledge of obstetrics and gynecology

improve their clinical reasoning ability

strengthen their practical operation skills

and enhance their autonomous learning ability.