Objective　To explore the effect of online PBL teaching in clinical practice of anesthesia nursing during the coronavirus disease 2019 (COVID-19) epidemic. Methods　From January 2020 may 2020

84 clinical nursing students who received anesthesia nursing teaching in our hospital were selected and randomized into the control group (n=42) and the experimental group (n=42). According to the different teaching methods

the control group adopted routine online teaching mode and the experimental group adopted online PBL teaching mode. SPSS 21.0 was used to compare scores of the theoretical knowledge

nursing evaluation

nursing plan

clinical operation and total scores of the two groups. Results　There was no significant difference in theoretical knowledge between the two groups (P>0.05). The nursing evaluation

nursing plan

clinical operation and total scores of the anesthesia nursing students in the experimental group were significantly higher than those in the control group(P<0.05)

and the experimental group had a significantly higher degree of teaching satisfaction than the control group (P<0.05). Conclusion　During the special period of the COVID-19 epidemic

the online PBL teaching has achieved good teaching effect of online practice of anesthesia nursing specialty

which has ensured classes suspended but learning continues

and improved the comprehensive examination results of the students. This teaching mode has gained good teaching satisfaction

worthy of clinical promotion and further study.